“For me being able to quantify aging is one of the most important endeavours in the field. There is a lot of emphasis on intervening in aging, to either reverse or slow it, but I would argue that there’s no way to test if you did that, if you can’t directly measure the thing that you’re trying to intervene in.”
In this episode, Morgan Levine, Assistant Professor at Yale, gives a sneak peek into the new epigenetic clock they are developing that is able to probe into multiple organ systems, as well as on a new approach on how to calculate clocks that is much more reliable, enabling to generate insights from methylation clocks with much smaller samples required.
The second talk is given by Jamie Justice, Assistant Professor at Wake Forest, and covered the current ways and strides the longevity field is making towards validating biomarkers of aging through clinical trials, shown on examples of a few senolytic trials they made. She also explains how exactly the TAME trial, which she is a coordinator of, should serve as a vehicle for the field to move further and have a flagship trial to validate new aging biomarkers against in the future.
Music:
Fast Talkin by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/
Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100590
Artist: http://incompetech.com/
I Knew a Guy by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/
Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100199
Artist: http://incompetech.com/
Remarks: The length of this recording has been altered.
Morgan Levine & Jamie Justice | On Biomarker Standardization